Azamulin - Azamulin

Azamulin
Klinik ma'lumotlar
ATC kodi	Yo'q;
Identifikatorlar
	IUPAC nomi (1S,2R,3S,4R,6R,7R,8R,14R) -4-Etil-3-gidroksi-2,4,7,14-tetrametil-9-oksotrisiklo [5.4.3.01,8] tetradek-6-il [(5-amino-1H-1,2,4-triazol-3-il) sulfanil] asetat;
CAS raqami	76530-44-4;
PubChem CID	16072188;
ChemSpider	17231671;
UNII	875AQ866X1;
ChEMBL	ChEMBL2103760;
Kimyoviy va fizik ma'lumotlar
Formula	C24H38N4O4S
Molyar massa	478.65 g · mol−1
3D model (JSmol )	Interaktiv rasm;
	Jilmayganlar CC [C @@] 1 (C [C @ H] ([C @@] 2 ([C @@ H] (CC [C @@] 3 ([C @ H] 2C (= O) CC3)] C @ H] ([C @@ H] 1O) C) C) C) OC (= O) CSc4nc ([nH] n4) N) C;
	InChI InChI = 1S / C24H38N4O4S / c1-6-22 (4) 11-16 (32-17 (30) 12-33-21-26-20 (25) 27-28-21) 23 (5) 13 (2) 7-9-24 (14 (3) 19 (22) 31) 10-8-15 (29) 18 (23) 24 / h13-14,16,18-19,31H, 6-12H2,1-5H3, (H3,25,26,27,28) / t13-, 14 +, 16-, 18 +, 19 +, 22-, 23 +, 24 + / m1 / s1; Kalit: FMHQJXGMLMSMLC-WBUYAQKGSA-N;

Azamulin a plevromutilin antibiotiklari.^[1] 2016 yildan boshlab^[yangilash], u AQSh yoki Evropada sotilmaydi.

Yilda farmakologik tadqiqotlar, modda jigar fermentlarining inhibitori sifatida ishlatiladi CYP3A4 va CYP3A5.^[2]^[3]

Adabiyotlar

^ Stresser DM, Broudy MI, Ho T, Cargill Idoralar, Blanchard AP, Sharma R va boshq. (2004 yil yanvar). "Insonning in vitro CYP3Aa ni azamulin bilan yuqori darajada selektiv ravishda inhibatsiyasi va inhibisyon qaytarilmasligini isbotlovchi dalillar". Giyohvand moddalar almashinuvi va joylashishi. 32 (1): 105–12. doi:10.1124 / dmd.32.1.105. PMID 14709627.
^ Ghosal A, Ramanatan R, Yuan Y, Xapangama N, Choddhuri SK, Kishnani NS, Alton KB (dekabr 2007). "CCR5 retseptorlari antagonisti bo'lgan vikrivirokning biotransformatsiyasida ishtirok etadigan odamning jigar sitoxromi P450 fermentlarini aniqlash". Giyohvand moddalar almashinuvi va joylashishi. 35 (12): 2186–95. doi:10.1124 / dmd.107.017517. PMID 17827338. S2CID 1866233.
^ Mitra R, Goodman OB (aprel, 2015). "CYP3A5 prostata saratoni hujayralarining o'sishini AR ning yadro translokatsiyasini engillashtirib tartibga soladi". Prostata. 75 (5): 527–38. doi:10.1002 / pros.22940. PMID 25586052.

Ushbu tizimli antibiotik bilan bog'liq maqola a naycha. Siz Vikipediyaga yordam berishingiz mumkin uni kengaytirish.

Klinik ma'lumotlar

ATC kodi	Yo'q
Identifikatorlar
IUPAC nomi (1S,2R,3S,4R,6R,7R,8R,14R) -4-Etil-3-gidroksi-2,4,7,14-tetrametil-9-oksotrisiklo [5.4.3.0^1,8] tetradek-6-il [(5-amino-1H-1,2,4-triazol-3-il) sulfanil] asetat
CAS raqami	76530-44-4
PubChem CID	16072188
ChemSpider	17231671
UNII	875AQ866X1
ChEMBL	ChEMBL2103760
Kimyoviy va fizik ma'lumotlar
Formula	C₂₄H₃₈N₄O₄S
Molyar massa	478.65 g · mol⁻¹
3D model (JSmol )	Interaktiv rasm
Jilmayganlar CC [C @@] 1 (C [C @ H] ([C @@] 2 ([C @@ H] (CC [C @@] 3 ([C @ H] 2C (= O) CC3)] C @ H] ([C @@ H] 1O) C) C) C) OC (= O) CSc4nc ([nH] n4) N) C
InChI InChI = 1S / C24H38N4O4S / c1-6-22 (4) 11-16 (32-17 (30) 12-33-21-26-20 (25) 27-28-21) 23 (5) 13 (2) 7-9-24 (14 (3) 19 (22) 31) 10-8-15 (29) 18 (23) 24 / h13-14,16,18-19,31H, 6-12H2,1-5H3, (H3,25,26,27,28) / t13-, 14 +, 16-, 18 +, 19 +, 22-, 23 +, 24 + / m1 / s1 Kalit: FMHQJXGMLMSMLC-WBUYAQKGSA-N